Chemotherapy

Drugs for chemotherapy generally fall into one of several categories. There are alkylating agents, anti-tumor antibiotics, Nitrosoureas, Antimetabolites, Topoisomerase Inhibitors, Mitotic Inhibitors, and Corticosteroid Hormones. This post concerns these more traditional treatments. Simply for background I will organize these drugs into their categories. This is taken from Wikipedia and provides a good overview of the current state of chemotherapy.

Alkylating and alkylating-like agents	Nitrogen mustards: (Chlorambucil, Chlormethine, Cyclophosphamide, Ifosfamide, Melphalan). Nitrosoureas:(Bendamustine, Carmustine, Fotemustine, Lomustine, Streptozocin). Platinum (alkylating-like): (Carboplatin, Cisplatin, Oxaliplatin, BBR3464, Satraplatin). Busulfan, Dacarbazine, Procarbazine, Temozolomide, ThioTEPA, Treosulfan, Uramustine
Antimetabolites	Folic acid: (Aminopterin, Methotrexate, Pemetrexed, Raltitrexed). Purine:(Cladribine, Clofarabine, Fludarabine, Mercaptopurine, Pentostatin, Thioguanine). Pyrimidine:(Capecitabine, Cytarabine, Fluorouracil, Floxuridine, Gemcitabine)
Spindle poison/mitotic inhibitor	Taxane: (Docetaxel, Paclitaxel). Vinca: (Vinblastine, Vincristine, Vindesine, Vinorelbine).
Cytotoxic/antitumor antibiotics	Anthracycline family: (Daunorubicin, Doxorubicin, Epirubicin, Idarubicin, Mitoxantrone, Pixantrone, Valrubicin) - streptomyces (Actinomycin, Bleomycin, Mitomycin, Plicamycin) - Hydroxyurea
Topoisomerase inhibitors	Camptotheca: (Camptothecin, Topotecan, Irinotecan, Rubitecan), Podophyllum:(Etoposide, Teniposide)
CI monoclonal antibodies	Receptor tyrosine kinase (Cetuximab, Panitumumab, Trastuzumab) - CD20 (Rituximab, Tositumomab) - other (Alemtuzumab, Bevacizumab, Gemtuzumab)
Photosensitizers	Aminolevulinic acid, Methyl aminolevulinate, Porfimer sodium, Verteporfin
Tyrosine kinase inhibitors	Cediranib, Dasatinib, Erlotinib, Gefitinib, Imatinib, Lapatinib, Lestaurtinib, Nilotinib, Sorafenib, Sunitinib, Vandetanib
Other	retinoids (Alitretinoin, Tretinoin) - Altretamine, Amsacrine, Anagrelide, Arsenic trioxide, Asparaginase (Pegaspargase), Bexarotene, Bortezomib, Denileukin diftitox, Estramustine, Ixabepilone, Masoprocol, Mitotane, Testolactone

Double-click The terms in red for definitions

* Anti-sense oligonucleotide therapy
* AROMATASE INHIBITORS
* TGF-Beta Receptors
* Tumor Necrosis Factor-alpha Receptors
* NF-kB pathway
* Lymphotxin
* proteasome Inhibitor
* T-Cell Receptor for Antigen (TCR)
* Calcineurin
* FK506
* Cyclosporine
* Bortezomib
* monoclonal antibodies
* Infliximab
* Glucocorticoids
* SMAD proteins
* Calcium
* JAK-STAT pathways
* Receptor Tyrosine Kinases
* proto-oncogene
* PDGF
* EGF
* Trastuzumab
* Cetuximab
* RAF
* RAS
* Interferons
* IL-2
* IL-4
* Growth Hormone
* Leptin
* Prolactin
* Erythropoetin
* Thrombopoetin
* GM-CSF
* Cox Inhibitors
* Thiols
* Nitric Oxide
* MDR
* Antioxidants
* Bevacizumab
* Angiogenisis
* Oncolytic viruses
* Seneca ValleyVirus-001
* VEGF Trap (aflibercept)
* Herpes Simplex Virus NV1020
* Mullerian Inhibiting Substance
* B-Catenin
* APC tumor suppressor gene
* Wnt ligand
* Cytokine Receptors
* Signal Transduction
* v-sis